Blog
Study the pathomechanism and potential treatment for Alzheimer’s disease
Hsiu-Mei Hsieh
Professor
Department of Life Science
Lab of Molecular Medicine
PhD in Developmental Biology program
From Children’s Hospital, University of Cincinnati, OH
Ministry of Science and Technology
Our researches mainly focus on the elucidation of pathomechanism and development of therapeutic strategies for diseases, including Alzheimer’s disease. Using disease models from cell lines, neuronal primary culture to mice, we have identified several potential treatments and the associate mechanisms of diseases. Total 18 SCI papers were published in last 5 years (2015-2019).
Techniques used in study
Cell culture (including primary cell culture)
Mouse culture
Mouse behavioral analyses (including Morris Water maze)
Western blot analysis
Immunofluorescent staining
Compound administration in mice
Our research achievements in the aspects of mechanism and treatment of Alzheimer’s disease
Publications
- MGCD0103, a selective histone deacetylase inhibitor, coameliorates oligomeric Aβ(25-35)-induced anxiety and cognitive deficits in a mouse model. CNS Neurosci Ther. 2019;25:175-186.
- Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice. Psychopharmacology (Berl). 2019; 236:763-773.
- Administration of Momordica charantia Enhances the Neuroprotection and Reduces the Side Effects of LiCl in the Treatment of Alzheimer’s Disease. Nutrients. 2018; 10: E1888.